To assess the pharmacokinetics, safety and tolerability of selumetinib in renal impaired subjects and healthy subjects

Exclusion Criteria

• all participants:
• 1.Subjects of Japanese or non Japanese Asian ethnicity.
• 2.Any one parent or grandparent (maternal or paternal) is Japanese or non-Japanese Asian (e.g. China, Taiwan, Korea, Philippines, Thailand, Vietnam and Malaysia). Asian Indians are acceptable.
• 3.Subjects who smoke more than 10 cigarettes or the equivalent in tobacco per day
• 4.In the opinion of the investigator, any evidence of additional severe or uncontrolled systemic disease (eg, currently unstable or uncompensated hepatic, cardiovascular, or respiratory disease) or laboratory finding, physical examination, hematology, clinical chemistry, urinalysis, vital signs, or 12-lead ECG that makes it undesirable for the subject to participate in the study.
• Exclusion renal impaired patients only:
• 5.Subjects with an active renal transplant (subjects who have previously received a renal transplant and are currently undergoing dialysis due to transplant failure may be enrolled).
• 6.Acute coronary syndrome within 6 months prior to administration of the investigational product.